Quetiapine (Seroquel): Clinical and Economic Outcomes 

A total of 50 patients were included in the mirror-design naturalistic study. The types of service utilization, medication costs, and overall costs were measured in a 1-year period prior to and then after quetiapine initiation. Clinical measures to document symptom improvement were done at medication initiation and 6 months later.

Results

• 72% reduction in inpatient utilization occurred after medication was initiated.
• 60% reduction in acute ER utilization
• 170% increase in outpatient services correlating with greater patient stabilization
• Overall mean costs savings of $12 per pt/month. (n=50)
• Significant  improvement in symptoms of schizophrenia PANSS score decreased by 20%-60%

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Service Utilization Changes 

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Intent to Treat: Cost Changes 

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Mean Cost Change Over 2 Years